:root{--ink:#153e41;--teal:#006c67;--petrol:#005653;--ground:#f5f8f7;--white:#fff;--muted:#46615f;--wash:#e2efec;--line:#c4d6d2;--radius:6px;--measure:1328px}
*{box-sizing:border-box}
html{scroll-behavior:smooth;scroll-padding-top:24px}
body{margin:0;background:var(--ground);color:var(--ink);font-family:"Trebuchet MS","Segoe UI","Gill Sans",sans-serif;font-size:18px;line-height:1.65}
button,input,select,textarea{font:inherit;color:inherit}
button,a,input{-webkit-tap-highlight-color:transparent}
button{cursor:pointer}
a{color:var(--teal);text-underline-offset:4px;text-decoration-thickness:1px}
a:hover{text-decoration-thickness:2px}
a:focus-visible,button:focus-visible,input:focus-visible,summary:focus-visible{outline:3px solid var(--petrol);outline-offset:4px}
img,svg{vertical-align:middle}
img{display:block;max-width:100%;height:auto}
button{border-radius:var(--radius)}
[hidden]{display:none!important}
.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}
.skip-link{position:fixed;z-index:20;top:8px;left:8px;transform:translateY(-180%);padding:12px 20px;background:var(--white);color:var(--petrol);border-radius:var(--radius)}
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.header-inner{max-width:var(--measure);margin:auto;min-height:108px;display:grid;grid-template-columns:minmax(0,1fr) minmax(0,640px) minmax(0,1fr);align-items:center;gap:32px}
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.search-field input:focus-visible{outline:0}
.search-field button:focus-visible{outline-offset:-5px}
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.site-tabs a:hover{border-bottom-color:var(--teal)}
.site-main{max-width:var(--measure);margin:0 auto;padding-bottom:72px;min-width:0}
.page-top{padding:38px 0 30px;max-width:1200px}
h1,h2,h3,h4,h5,h6{font-family:inherit;line-height:1.2;font-weight:700;overflow-wrap:break-word}
h1{font-size:46px;letter-spacing:-1.3px;margin:0;max-width:1250px}
.page-home h1{font-size:50px}
.lead-abstract{font-size:20px;line-height:1.55;margin:14px 0 0;max-width:1000px}
h2{font-size:30px;margin:42px 0 18px;letter-spacing:-.6px}
h3{font-size:23px;margin:30px 0 14px;letter-spacing:-.25px}
h4{font-size:20px;margin:26px 0 12px}
p{margin:0 0 20px}
ul,ol{padding-left:26px;margin:14px 0 24px}
li{margin-bottom:9px}
code,pre{font:inherit;overflow-wrap:anywhere}
sup{font-size:.75em}
blockquote{margin:24px 0;padding:16px 24px;border-left:6px solid var(--teal);background:var(--wash)}
hr{border:0;height:3px;background:var(--wash);margin:36px 0}
.database-tools{display:flex;justify-content:space-between;gap:24px;align-items:center;margin:0 0 20px}
.filter-chips{display:flex;flex-wrap:wrap;gap:8px}
.filter-chips button{min-height:44px;padding:8px 14px;border:0;background:var(--wash);color:var(--ink);font-size:16px}
.filter-chips button[aria-pressed=true]{background:var(--teal);color:var(--white);font-weight:700}
.filter-chips button:hover{background:var(--petrol);color:var(--white)}
#record-count{margin:0;white-space:nowrap;color:var(--muted);font-size:16px}
table{border-collapse:collapse;width:100%;text-align:left}
th,td{vertical-align:top}
.sourcing-record{border-top:4px solid var(--teal);background:var(--white);margin:0;border-bottom:0}
.sourcing-record th,.sourcing-record td{padding:18px 24px;vertical-align:middle}
.sourcing-record th{width:40%;font-weight:400}
.sourcing-record th>strong{display:block;font-size:20px;line-height:1.3}
.pin-label{display:flex;align-items:center;gap:8px;color:var(--muted);font-size:16px;line-height:1.25;margin:0 0 6px}
.pin{color:var(--teal);flex:none}
.sourcing-record td>strong{font-size:20px;display:block;line-height:1.3}
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.compound-database{background:var(--white);font-size:16px;line-height:1.55;table-layout:fixed}
.compound-database thead{background:var(--teal);color:var(--white)}
.compound-database thead th{padding:16px 22px;font-weight:400;line-height:1.35}
.compound-database thead th:nth-child(1){width:22%}
.compound-database thead th:nth-child(2){width:32%}
.compound-database thead th:nth-child(3){width:12%}
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.compound-record:hover{background:var(--ground)}
.compound-record h3{margin:0 0 9px;font-size:20px;line-height:1.3;letter-spacing:-.25px}
.compound-record h3 a{text-decoration:none}
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.compound-record p{margin:0}
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.compound-class span+span{display:block;margin-top:4px}
.stage{font-weight:700;font-size:16px;color:var(--petrol)}
.record-link{font-size:16px;line-height:1.4;display:inline-flex;align-items:center;min-height:44px;gap:7px}
.empty-state{padding:28px;background:var(--wash)}
.document-photo{margin:46px 0;overflow:hidden;border-radius:var(--radius);background:var(--wash)}
.document-photo img{width:100%;aspect-ratio:1.8;object-fit:cover;color:var(--ink);font-size:16px}
.page-home>.site-main>.document-photo img{aspect-ratio:2.4}
.meta-strip{display:flex;flex-wrap:wrap;gap:12px 28px;background:var(--wash);padding:16px 22px;font-size:16px;line-height:1.5;margin:26px 0 34px;border-radius:var(--radius)}
.meta-strip strong{font-weight:700}
.meta-cell{min-width:150px;flex:1}
.meta-label{color:var(--muted);font-size:16px}
.meta-val{font-weight:700}
.record-layout,.topic-layout{display:grid;grid-template-columns:292px minmax(0,1fr);gap:58px;align-items:start}
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.record-facts>h2{font-size:22px;margin:0;background:var(--teal);color:var(--white);padding:18px 20px;border-radius:6px 6px 0 0;letter-spacing:0}
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dt{font-size:16px;font-weight:700;color:var(--petrol);margin:16px 0 5px}
dt:first-child{margin-top:0}
dd{margin:0 0 14px;overflow-wrap:anywhere}
dd:last-child{margin-bottom:0}
dd span+span{display:block}
.sourcing-note{font-size:16px;line-height:1.5;margin:0 0 28px;border-top:4px solid var(--teal);border-bottom:2px solid var(--wash)}
.sourcing-note tr{display:block}
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.sourcing-note th{padding-top:14px;color:var(--muted);font-size:16px;font-weight:400}
.sourcing-note td{padding:8px 0 16px}
.sourcing-note td>strong,.sourcing-note td>span{display:block;margin-bottom:8px}
.sourcing-note a{display:inline-flex;min-height:44px;align-items:center;gap:12px}
.availability-note{color:var(--muted)}
.page-topic .site-main>.sourcing-note tr{display:grid;grid-template-columns:220px 1fr;gap:24px;padding:0 20px;background:var(--white)}
.page-topic .site-main>.sourcing-note td{display:flex;flex-wrap:wrap;align-items:center;gap:4px 24px;padding:14px 0}
.page-topic .site-main>.sourcing-note td>span,.page-topic .site-main>.sourcing-note td>strong{margin:0}
.key-study{padding:0 0 24px;margin-bottom:18px;border-bottom:2px solid var(--wash);overflow-wrap:anywhere}
.key-study h3{font-size:18px;margin:20px 0 12px}
.key-study p{margin:0 0 10px}
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.sidebar-panel-header,.sidebar-card-title{font-size:18px;font-weight:700;margin:0 0 10px;padding:14px 0 0;color:var(--petrol)}
.sidebar-panel-body{padding:0}
.toc-list,.toc-nav ul{list-style:none;padding:0;margin:0 0 28px}
.toc-list li,.toc-nav li{margin:0;border-bottom:1px solid var(--line)}
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.toc-list a:hover,.toc-nav a:hover{text-decoration:underline}
.sidebar-panel a:not(.toc-list a),.sidebar-btn{display:inline-flex;min-height:44px;align-items:center}
.spec-dl{margin:0;padding:0}
.narrative{min-width:0;max-width:978px;overflow-wrap:break-word}
.narrative>h2:first-child{margin-top:0}
.abstract{padding:24px 28px;background:var(--wash);border-radius:var(--radius);margin:0 0 32px}
.abstract p:last-child{margin-bottom:0}
.monograph-kicker{font-size:18px;font-weight:700;margin-bottom:14px}
.kicker-badge{font-size:18px;font-weight:700}
.narrative .abstract{font-size:18px}
.scientific-figure{margin:32px 0;overflow:auto;background:var(--white);border-radius:var(--radius)}
.scientific-figure img[data-diagram]{width:100%;min-width:720px;max-width:none}
figcaption{font-size:16px;line-height:1.6;padding:16px 0;color:var(--muted)}
.scientific-figure figcaption{padding:16px 20px;position:sticky;left:0;max-width:100%}
.technical-caption{margin:24px 0;padding:12px 24px;background:var(--wash);border-radius:var(--radius)}
.technical-caption figcaption{padding:4px 0}
.legacy-caption-flow{display:block}
.retained-content>.monograph-content{max-width:1000px;margin:0 auto}
.retained-content>h2{margin-top:24px}
.section-header-bar{background:var(--petrol);color:var(--white);padding:24px 30px;margin:46px 0 28px;display:flex;gap:24px;justify-content:space-between;align-items:center;border-radius:var(--radius)}
.section-header-bar h2{font-size:28px;line-height:1.3;margin:0;color:var(--white)}
.section-header-bar a{color:var(--white);font-size:16px;min-height:44px;display:inline-flex;align-items:center}
.table-scroll{overflow:auto;max-width:100%;margin:28px 0;border-radius:var(--radius);background:var(--white)}
.table-scroll table{font-size:16px;line-height:1.6;min-width:680px}
.table-scroll thead,.table-scroll tr:first-child:has(th){background:var(--teal);color:var(--white)}
.table-scroll th,.table-scroll td{padding:16px 18px;border-bottom:1px solid var(--line)}
.table-scroll th{font-weight:700}
.table-scroll a{overflow-wrap:anywhere}
.regulatory-notice,.warning-box,.disclaimer-box,.info-box,.research-note,.methodology-note-plate,.note{padding:22px 26px;margin:28px 0;background:var(--wash);border-radius:var(--radius);border:0;font-size:18px}
.regulatory-notice-title{font-size:20px;font-weight:700;margin-bottom:12px}
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.reference-list,.references-list,.ref-list{font-size:16px;line-height:1.7;padding-left:26px}
.reference-list li,.references-list li,.ref-list li{padding:8px 0 12px;margin:0;border-bottom:1px solid var(--line);overflow-wrap:anywhere}
.citation{font-size:inherit}
.topic-body{max-width:1040px}
.topic-body .compound-cluster-grid{display:block}
.topic-body .compound-card{padding:20px 0;border-bottom:2px solid var(--wash)}
.topic-body .compound-card-footer a{display:inline-flex;align-items:center;min-height:44px}
.footer-inner{max-width:var(--measure);margin:auto;padding:44px 0 24px}
.site-footer{background:var(--wash);color:var(--ink);font-size:16px;line-height:1.65;border-top:12px solid var(--teal)}
.footer-grid{display:grid;grid-template-columns:2fr 1fr 1fr 1.4fr;gap:40px}
.footer-heading{font-weight:700;color:var(--petrol);font-size:18px;margin:0 0 16px}
.footer-links{list-style:none;padding:0;margin:0}
.footer-links li{margin:0}
.footer-links a{display:inline-flex;align-items:center;min-height:44px;text-decoration:none;line-height:1.45}
.footer-links a:hover{text-decoration:underline}
.footer-bottom{display:flex;justify-content:space-between;gap:20px;border-top:2px solid var(--line);padding:24px 0 0;margin-top:28px}
@media(min-width:1441px){.site-main,.header-inner,.site-tabs,.footer-inner{max-width:1328px}}
@media(max-width:1439px){.site-main,.header-inner,.site-tabs,.footer-inner{margin-left:40px;margin-right:40px}.header-inner{grid-template-columns:minmax(0,1fr) minmax(0,600px) minmax(0,1fr);gap:24px}.record-layout,.topic-layout{gap:40px;grid-template-columns:280px minmax(0,1fr)}.compound-record>th,.compound-record>td,.compound-database thead th{padding-left:18px;padding-right:18px}}
@media(min-width:1440px){.site-main,.header-inner,.site-tabs,.footer-inner{width:calc(100% - 112px)}}
@media(max-width:1050px){.header-inner{grid-template-columns:240px minmax(0,1fr)}.header-index{display:none}.compound-record>th,.compound-record>td{padding:18px 14px}.compound-database thead th{padding:14px}.record-layout,.topic-layout{grid-template-columns:244px minmax(0,1fr);gap:30px}.sourcing-record th,.sourcing-record td{padding:16px}.sourcing-record th>strong,.sourcing-record td>strong{font-size:18px}.sourcing-record a{font-size:16px}.footer-grid{grid-template-columns:1.6fr 1fr;gap:32px}}
@media(max-width:800px){
 .site-main,.header-inner,.site-tabs,.footer-inner{margin-left:20px;margin-right:20px}
 .header-inner{grid-template-columns:1fr auto;gap:14px;min-height:0;padding:18px 0}
 .wordmark{font-size:22px;min-height:40px;gap:10px}.wordmark-description{font-size:16px;margin-top:4px}.wordmark-symbol{width:23px;height:28px;gap:3px}
 .site-search{grid-column:1/-1;grid-row:2}.search-field{min-height:50px}.search-field input{font-size:16px;padding:12px}.search-field button{min-height:48px;min-width:48px}
 .js .menu-toggle{display:inline-flex;gap:14px;align-items:center;justify-content:center;min-height:44px;padding:6px 12px;border:2px solid var(--white);background:transparent;color:var(--white);font-size:16px}
 .menu-toggle:focus-visible{outline-color:var(--white)}
 .site-tabs{display:flex;flex-wrap:wrap;gap:0 24px;min-height:0}
 .js .tabs-band:not(.is-open){display:none}.tabs-band.is-open .site-tabs{display:grid;grid-template-columns:1fr 1fr;padding:10px 0;gap:0 20px}
 .site-tabs a{min-height:48px;padding:10px 0;border-width:3px;font-size:16px}
 .page-top{padding:24px 0 22px}.page-top h1,.page-home h1{font-size:30px;line-height:1.12;letter-spacing:-.65px}.page-topic .page-top h1{font-size:27px}
 .lead-abstract{font-size:18px;line-height:1.5;margin-top:12px}
 .database-tools{display:block;margin-bottom:16px}.filter-chips{gap:6px}.filter-chips button{font-size:16px;padding:8px 11px}
 #record-count{margin-top:10px}
 .sourcing-record,.sourcing-record tbody{display:block}.sourcing-record tr{display:grid;grid-template-columns:1fr 1fr;gap:4px 14px;padding:14px 16px}
 .sourcing-record th{grid-column:1/-1;width:auto;padding:0}.sourcing-record th>strong{font-size:20px}.pin-label{font-size:16px;margin-bottom:5px}
 .sourcing-record td{padding:8px 0 0;display:flex;flex-direction:column;justify-content:center}.sourcing-record td>strong{font-size:18px}.sourcing-record td>span{line-height:1.35;font-size:16px;margin-top:3px}.sourcing-record td:last-child{text-align:left}
 .sourcing-record a{font-size:16px;line-height:1.35;gap:6px}
 .compound-database,.compound-database tbody,.compound-database thead,.compound-database thead tr{display:block}
 .compound-database thead th{display:none}.compound-database thead th:first-child{display:block;width:100%;padding:12px 16px;font-size:18px}
 .compound-database .group-row{display:block}.compound-database .group-row th{display:block;padding:12px 16px}.compound-database .group-row h3{font-size:17px}
 .compound-record{display:grid;grid-template-columns:1fr 1fr;gap:14px 20px;padding:20px 16px;border-bottom:2px solid var(--wash)}
 .compound-record>th,.compound-record>td{display:block;padding:0;border:0;min-width:0}.compound-record>th,.compound-record>td:nth-child(2){grid-column:1/-1}
 .compound-record>td:nth-child(4){grid-column:1/-1}.compound-record>td:last-child{grid-column:1/-1}
 .compound-record>td:not(:nth-child(2)):not(:last-child)::before{content:attr(data-label);display:block;color:var(--muted);font-size:16px;margin-bottom:5px}
 .compound-record h3{font-size:22px}.compound-class{margin-top:6px}
 .record-link{gap:18px}.record-layout,.topic-layout{display:flex;flex-direction:column;gap:32px}.record-facts,.topic-navigation,.narrative{width:100%;max-width:100%}
 .record-dl{padding:18px 20px}.record-dl dd{margin-bottom:16px}.record-facts>h2{padding:14px 20px}.record-facts .legacy-facts{margin-top:28px}
 .topic-navigation{order:0}.narrative{order:1}
 .sourcing-note{margin-bottom:22px}.page-topic .site-main>.sourcing-note tr{display:block;padding:0 16px}.page-topic .site-main>.sourcing-note td{display:block;padding:8px 0 14px}.page-topic .site-main>.sourcing-note td>span{margin:6px 0}
 .abstract{padding:20px}.abstract p{font-size:18px}
 .meta-strip{gap:10px 18px;padding:16px 18px;margin:22px 0 28px}.meta-strip>span{display:block}
 h2{font-size:26px;margin-top:34px}h3{font-size:22px}
 .section-header-bar{padding:22px 20px;display:block;margin-top:32px}.section-header-bar h2{font-size:26px}.section-header-bar a{margin-top:12px}
 .document-photo{margin:32px 0}.document-photo img,.page-home>.site-main>.document-photo img{aspect-ratio:1.6}
 .table-scroll{margin:24px 0}.scientific-figure{margin:26px 0}.scientific-figure figcaption{padding:16px}
 .regulatory-notice,.warning-box,.disclaimer-box,.info-box,.research-note,.methodology-note-plate,.note{padding:20px;margin:24px 0}
 .footer-grid{grid-template-columns:1fr 1fr;gap:24px}.footer-col:first-child,.footer-col:last-child{grid-column:1/-1}.footer-bottom{display:block}.footer-bottom span{display:block;margin-bottom:12px}
 .technical-caption{padding:16px 18px}.site-main{padding-bottom:48px}
}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}}
@media print{.site-header,.site-footer,.filter-chips,.search-results,.menu-toggle{display:none}.site-main{width:auto;margin:0}.record-layout,.topic-layout{display:block}.narrative{max-width:none}.document-photo{display:none}a{color:inherit}.compound-record{break-inside:avoid}}